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A separate study published in August 2025 found patients prescribed semaglutide or tirzepatide for Type 2 diabetes had an increased risk of NAION and other optic nerve disorders, but the overall risk was very low
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10.1038/s41591-024-03355-2 [DOI] [PMC free article] [PubMed] [Google Scholar] 68.Cui SS, Feng XB, Zhang BH, Xia ZY, Zhan LY (2020) Exendin-4 attenuates pain-induced cognitive impairment by alleviating hippocampal neuroinflammation in a rat model of spinal nerve ligation
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