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However, plasma concentrations of semaglutide at steady state are estimated to be about 100 times lower than the IC 50 values for OATP1B1/3 (3.50 μM and 2.95 μM, respectively).56 Moreover, when BSA was added, the inhibitory effect disappeared or was diminished, probably due to the binding of the fatty acid residues of GLP-1 RAs and a dual GLP-1/GIP RA to BSA.70 Table 3
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