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Trulicity Device Design features: Single-use, pre-filled pen Hidden needle (never seen by patient) One-button activation Automatic injection process No dose dialing required User experience: Often described as very easy to use Good for needle-phobic patients Minimal steps: attach, press, hold Automatic needle insertion and retraction Potential limitations: Fixed dose per pen (less flexibility) More waste (entire device discarded) Must match prescription to available pen strengths Ozempic Device Design features: Multi-dose pen (typically 4-week supply) Requires attaching needle Dose must be dialed Manual injection process Visible needle (though small) User experience: More steps required than Trulicity Requires dose selection Needle attachment needed More typical of traditional insulin pens Potential advantages: More flexible dosing Less packaging waste May be easier to verify dose delivery Device Comparison Does Device Matter

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Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycaemic control (Lira-1): a randomised, double-blind, placebo-controlled trial