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To substantiate this hypothesised mechanism for the effect of GLP-1 in the OB of WD mice, we performed OGTT to test whether prior IP injection of an α 2 -adrenergic receptor agonist, UK14304 23 , could modulate the effect of bulbar Ex4 administration (Fig
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NICE guidance (NG28) recommends GLP-1 receptor agonists in type 2 diabetes only for specific patients, typically when other treatments have proven insufficient and when certain BMI thresholds are met
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