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Recent Advances in Incretin-Based Pharmacotherapies for the Treatment of Obesity and Diabetes[J].Frontiers in endocrinology, 2022, 13:838410.DOI:10.3389/fendo.2022.838410

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Indeed, the pharmacokinetic and pharmacodynamics of any drug taken by mouth should be appraised considering the role of the microbiota, as the varied efficacy of some chemotherapeutics such as 5-FU has been proven to directly depend on this host-microbiota metabolism (400)