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Furthermore, GIP(3-30)NH 2 has been used to demonstrate an uncoupling of the otherwise coupled processes of bone resorption and formation assessed by a decrease in CTX and a temporary increase in the bone formation marker procollagen type 1 amino terminal propertied (P1NP) in healthy individuals (100)

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In pharmacological studies, alanine scanning mutagenesis shows that residues in the transmembrane region and extracellular loops are critical for the differential signaling response produced by different ligands(Furness et al., 2018