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1 The approval of liraglutide, semaglutide, and tirzepatide for chronic weight management has significantly expanded their use
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Short-acting GLP-1RAs (exenatide [ t 1/2 of 2.4 hours] and lixisenatide [ t 1/2 of 2–4 hours] administered before meals twice-daily and once-daily, respectively) exhibit intermittent GLP-1 receptor activation translating into potent deceleration of upper gastrointestinal motility, an effect which is sustained during prolonged treatment
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