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In the periphery, posttranslational processing of preproglucagon in the alpha-cells of the pancreas produces glucagon and a small amount of GLP-1 whereas the main source of peripheral GLP-1 production occurs through the posttranslational processing of preproglucagon in the L-cells of the gut (reviewed in Holst, 2007 and Campbell and Drucker, 1992
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Phase III trial data showed that Saxenda, in combination with a reduced-calorie diet and increased physical activity, resulted in significantly greater weight loss than diet and physical activity alone
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